The first historical record of psilocybin use dates back to Mesoamerica. Fungi were a prominent feature in Mixtec cultures, with over 5,000 different names of common edible mushrooms known across Mexican languages. A codex known as the “Yuta Tnoho” that belonged to the Mixtec culture in the 1500s BCE depicted religious and medicinal ritual ingestion of psilocybin-containing mushrooms.